Storage space requirements with a large refrigeration capacity they use refrigerants types R22 and R404A. This research to develop alternative technologies to meet the needs of storage space with a large refrigeration capacity. Liquid suction subcooling technology is typically used to obtain improve refrigeration effect at vapor compression refrigeration system. Liquid suction heat exchanger subcooling used a type of tube in tube heat exchanger installed between the condenser and the capillary tube before entering the evaporator. Refrigerant used in this research is R22, R404A, and mixture refrigerant R290/R600a [50:50]. In steady state condition with subcooling temperature evaporator with R290/R600a lower reaches −30°C, lower than R404a and R22 is −24°C and −22°C. Liquid suction heat exchanger subcooling effect on ΔTsub. The cooling effect by the mixture refrigerant of R290/R600a greater than R404a and R22, and liquid suction heat exchanger increase refrigeration capacity index (RCI). The average increase in RCI respectively 3.91%, 7.78%, and 11.87%. Work compressor and compressor work index (CWI) with a mixture refrigerant of R290/R600a greater than R404a and R22, the average work compressor and the working compressor index is greatest mixture refrigerant R290/R600a. CWI respectively is an average of 5.68%, 8.82%, and 11.82%. The average COP, their, liquid suction heat exchanger, respectively are 3.38, 3.18 and 2.63. COPRS with a mixture refrigerant of R290/R600a [50:50] is bigger than the R22 and R404a, and the average COPRS is 5:01%, 5.95%, and 7:41%. A mixture refrigerant R290/R600a [50:50] have the same characteristics as R404a, which can be used as a substitute for refrigerant R22 and R404A.