Global warming is the result of the use of Chloro Fluoro Carbon (CFC) and Hydro Flouro Carbon (HFC) refrigerants. CFC and HFC refrigerants are not environmentally friendly in air conditioning systems. Researchers conducting the research to find an alternative refrigerant with hydrocarbon and the use of liquid suction heat exchanger (LSHX) subcooling in the vapor compression refrigeration system. One kind of LSHX is heat exchanger between tube to tube. Retrofit refrigerant is used to find a replacement refrigerant for R22, R134a, R404A with R600, and mixture refrigerant R290/R600a in the ratio 50:50. From the analysis are conclude that the increases of degree of subcooling temperature significantly affects to the effectiveness of LSHX, increase the refrigeration capacity and also refrigeration capacity index, increase the compressor of work, compressor work of index, COP and COP index. The parameters of the indicators that mixture the refrigerant R290/R600a in the ratio of 50:50 can be used as a substitution for R404A and R22, while the R600 refrigerant can be used as a substitution for R134a in the vapor compression refrigeration system with LSHX.